Palmitoyl Tripeptide-1 As part of the Matrixyl 3000 and is made up of 3 amino acids which are the building blocks for the protein found on the skin. Containing the peptide sequence of glycine-histidine-lysine (GHK) it can increase the skin’s ability to absorb ingredients that are topically applied to the skin. It is with this trio of peptides that can restore the collagen levels in the skin by tricking it into thinking collagen has broken down meaning it is time to produce more, the result of this is a face that is full of youthful bounce. With its ability to produce extra volume of collagen in the skin making it improve a large amount of skin concerns, from fine lines, wrinkles, rough texture, improving skin tone and giving it a lifting effect to skin. In other words, this ingredient is a powerhouse anti-ageing ingredient.

Stem Cell Cream with Multiple Peptides

If you're looking to turn back the clock on aging skin, Stem Cell Cream with Multiple Peptides is your ultimate skincare breakthrough. This luxurious moisturizer combines the regenerative power of Swiss Apple Stem Cells with three advanced peptides—Acetyl Hexapeptide-8 (Argireline), Palmitoyl Tripeptide-1, and Palmitoyl Tetrapeptide-7—for a visibly smoother, firmer, and more radiant complexion.

The plant stem cells, sourced from the rare Swiss Uttwiler Spätlauber apple, stimulate your skin’s natural repair and renewal processes, prolonging the life of skin stem cells and improving elasticity. Meanwhile, the peptides target expression lines, enhance collagen synthesis, and reduce signs of fatigue. This formula is further boosted by Malachite Extract, a mineral-rich antioxidant that fights environmental damage and stress-induced aging. Together, these powerhouse ingredients work synergistically to smooth fine lines, restore firmness, and promote youthful skin resilience.

Benefits of Stem Cell Cream with Multiple Peptides

1. Reduces Fine Lines & Expression Wrinkles

   • Acetyl Hexapeptide-8 relaxes facial tension to soften visible lines, especially around the eyes and mouth.

2. Boosts Collagen & Elastin Production

   • Palmitoyl Tripeptide-1 and Tetrapeptide-7 work to firm, plump, and strengthen the skin’s structure.

3. Activates Skin Regeneration

   • Swiss Apple Stem Cells prolong the vitality of your skin’s own stem cells, encouraging youthful renewal.

4. Protects Against UV Damage & Environmental Stress

   • Malus Domestica and Malachite Extract offer powerful antioxidant protection against premature aging.

5. Improves Skin Elasticity & Density

   • Reinforces fibroblast function to maintain firm, supple skin and enhance wound healing over time.

Benefits of DMAE (Dimethylaminoethanol) in Skincare:

• Lifting & Tightening: Known as a "lifting" agent, DMAE increases skin firmness, particularly on the forehead and neck. It works by increasing the contractile capacity of muscle cells, providing an immediate firming effect.

• Reduces Wrinkles: Studies show it can reduce the depth of fine lines and forehead wrinkles over time.

• Improves Collagen Structure: DMAE has been shown to increase the thickness of collagen fibers in the dermis, leading to better skin structure.

• Antioxidant Properties: It acts as a membrane stabilizer to protect against environmental stressors.

• Hydration: It can improve the skin's moisture barrier.

The allure of eternal youth has captivated humanity for centuries, and the quest for radiant, age-defying skin has led to the discovery of groundbreaking ingredients in the realm of skincare. Among these cutting-edge innovations, plant stem cell cream infused with potent peptides has emerged as a frontrunner in the battle against the relentless march of time. 

This luxurious elixir harnesses the regenerative power of Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, and Palmitoyl Tetrapeptide-7, a trio of peptides renowned for their ability to smooth fine lines, firm sagging skin, and restore a youthful glow. The Acetyl Hexapeptide-8, also known as Argireline, works by gently relaxing facial muscles, thereby minimizing the appearance of expression lines and wrinkles. Meanwhile, Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 work in synergy to stimulate collagen production, the protein essential for maintaining skin's elasticity and suppleness. When combined with the regenerative properties of plant stem cells, which possess the extraordinary ability to self-renew and differentiate into various cell types, this powerful blend of peptides creates a veritable fountain of youth for the skin.

By harnessing the wisdom of nature and the advancements of science, plant stem cell cream with peptides offers a transformative experience, unveiling a complexion that radiates with the luminosity and vitality of youth.

Apple Extract (Malus Domestica Cell Culture) Skin Benefits:

The first extract in our arsenal is the Malus Domestica Fruit Cell Culture Extract. We know, a bit of a mouthful… This extract, however, doesn’t come from just any old apple tree. The apple itself is more commonly known as the Swiss Apple and comes from a very rare tree called Uttwiler Spätlauber that is native to the Swiss Alps. The tree is so rare that the extract isn’t even from the apple itself because the tree is endangered and protected.

As the name implies, the extract is instead made from a cell culture of the Swiss apple. Using the cell cultures allows for a steady supply of these cells without driving the Uttwiler Spätlauber tree to extinction. Learn what Malus Domestica Cell Culture can do for your skin!

Increases the Longevity of Skin Stem Cells

This extract has been shown to prolong the life of our skin’s stem cells. Stem cells only make up about 2-7% of our skin cells but are responsible for the constant renewal of our skin through the creation of new cells.

All of the cells in our body go through a life cycle much shorter than our own and at the end of the cell’s life cycle, it dies and is replaced by new cells. As we age, the ability of our stem cells to produce new cells becomes less efficient and eventually stops. As less and less new cells are created, the aged and dying cells begin to outnumber them, this leads to a decline in the skin’s appearance. By prolonging the life of our skin’s stem cells, we can put off the onset of visibly aged skin, giving us younger-looking skin for a longer time. 

Protects Against UV Radiation

The second-largest contributor to aging skin is caused by environmental factors like air pollutants and too much sun exposure. The sun’s damaging UV radiation can cause free radicals to form on our skin. These free radicals are known to prematurely age the skin, leading to wrinkles, fine lines, and sagging skin. This extract has a high antioxidant content which can be effective in removing and neutralizing harmful free radicals from the skin.

A recent study proved the extract’s ability to protect the cells from UV damage. They tested its effectiveness by placing two groups of cells under intense UV light. The first group was an untreated group of cells and showed a loss of about 50% of the cells after the UV exposure. The second group of cells was treated with the apple extract and only showed the loss of a few cells after an equal dose of UV radiation. 

Maintains Skin Strength and Elasticity

Although this extract has been shown to increase the longevity of our stem cells, they only make up a very small percentage of our skin cells. Luckily, it also increases the productivity and longevity of cells called fibroblasts, which make up the majority of our skin cells. These cells are responsible for making proteins like collagen and elastin that maintain the shape and appearance of our skin, as well as, play a major role in the wound healing process.

As we age, our body naturally begins to lose these proteins faster and produce less of them. This weakens the skin's structure and causes it to sag and develop a crepey appearance. The apple extract has been shown to not only reduce the effects that aging has on these cells but even reverse them to some degree!

Reduces Wrinkles and Fine Lines

The combination of this extract’s antioxidants, as well as, its ability to restore the function of both our stem cells and fibroblast cells makes it a triple threat for fending off wrinkles and fine lines!

While the antioxidants remove free radicals that can cause the skin to prematurely age, the increased presence and function of both cell types will lead to more of the skin proteins collagen and elastin. This will keep the skin from sagging, increase the skin’s density, and give the skin an overall younger appearance. 

Malus Domestica Cell Culture Extract Topical Benefits:

• UV protection
• Antioxidant
• Reduce wrinkles
• Reduce fine lines
• Increase skin elasticity
• Tighten skin
• Increase skin density
• Improve wound healing

How do Swiss apple stem cells work?

Swiss apple stem cells have been found to have remarkable anti-aging properties. They work by stimulating the skin's stem cells, which are responsible for regenerating new skin cells. As we age, the number and activity of our skin's stem cells decline, leading to the visible signs of aging such as wrinkles, fine lines, and sagging skin.

By applying Joli Visage Stem Cell Moisturizing Cream, containing Swiss apple stem cells and multiple peptides, we can replenish and activate our skin's stem cells, promoting the production of new, healthy skin cells. This can result in smoother, firmer, and more youthful-looking skin.

Smooth evenly over face, under eyes, and neck.  

Suggested Precautions: For external use only. Avoid direct contact with the eyes. If contact occurs, rinse thoroughly for 15 minutes with water. If redness or irritation occurs, discontinue use. Keep out of reach of children. Store in a cool, dry place, away from excessive heat and cold.

Key Ingredients: Spilanthes Acmella Flower Extract, 2% Malus Domestica Fruit Cell Culture Extract*, Malachite Extract 

Ingredients: Deionized Water, C12-C15 Alkyl Benzoate, Glycerin, Butyrospermum Parkii (Shea) Butter, Cetearyl Alcohol, Caprylic/Capric Triglyceride, Stearic Acid, Titanium Dioxide, Arachidyl Alcohol, Organic Mangifera Indica (Mango) Seed Butter, Phenoxyethanol, Behenyl Alcohol, Butylene Glycol, Arachidyl Glucoside, Avena Sativa (Oat) Kernel Flour, DMAE Bitartrate, Sodium Ascorbyl Phosphate, Tetrahydrocurcumin, Xanthan Gum, Phospholipids, Lipoic Acid, Tetrahexyldecyl Ascorbate, Tocopheryl Acetate, Potassium Sorbate, Malus Domestica Fruit Cell Culture Extract, Leuconostoc/Radish Root Ferment Filtrate, Spilanthes Acmella Flower Extract, Steareth-20, Malachite Extract, Retinol, Sodium Hyaluronate, Tetrahydrodemethoxydiferuloylmethane, Carbomer, Hesperidin Methyl Chalcone, Polysorbate 20, Daucus Carota Sativa (Carrot) Root Extract, Tetrahydrobisdemethoxydiferuloylmethane, Glucose, EDTA, Sodium Benzoate, Citric Acid, Dipeptide-2, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Acetic Acid After (Day 28) 

 *Malus Domestica is a patented liposomal preparation based on the stem cells of a rare Swiss apple.

The study below was conducted by an independent lab.  Anti-aging effect on crow’s feet. 

The major difference between these two "Best Selling Formulations."

Reviving Matrixyl 3000 Deep Wrinkle Cream is a peptide-heavy firming formula designed for repair. At the same time, the second is a complex "stem cell" multi-corrector focused on cellular renewal, brightening, and more aggressive anti-aging.

1. Peptide Focus (First Product) - Reviving Matrixyl 3000 Deep Wrinkle Cream

This product is centered on Matrixyl peptides (Palmitoyl Tetrapeptide-7 and Palmitoyl Hexapeptide-12). It is designed to signal the skin to produce more collagen and elastin. 

• Key Action: Repairing the skin barrier and improving elasticity.

• Unique Features: Contains Peppermint Oil and Green Tea Extract for soothing and antioxidant protection, but its ingredient list is leaner and more targeted toward basic hydration and peptide delivery. 

2. Stem Cell & Multi-Active Focus (Second Product) - Stem Cell Cream with Multiple Peptides

This formula is much more complex, featuring a "kitchen sink" approach to anti-aging with several high-potency actives not found in the first product.

• Key Action: Cellular longevity and skin "lifting."

• Differentiation Factors:

• Plant Stem Cells: Uses Malus Domestica (Apple) Fruit Cell Culture to support skin cell vitality.

• Retinol: Includes Vitamin A for cell turnover, which is absent in the first product.

• DMAE & Lipoic Acid: These are "lifting" and metabolic antioxidants often associated with Perricone MD-style formulations to help with skin firmness and tone.

• Brighteners: Contains Vitamin C (Sodium Ascorbyl Phosphate and Tetrahexyldecyl Ascorbate) and Curcumin for significant brightening and dark spot correction.

• Advanced Peptides: In addition to the peptides in the first product, it adds Acetyl Hexapeptide-8 (often called "Botox in a jar" for its effect on expression lines). 

Summary Comparison Table